Experimental Autoimmune Encephalomyelitis Model for Discovery of New Therapy for Multiple Sclerosis
نویسندگان
چکیده
Experimental autoimmune encephalomyelitis (EAE) is the most widely accepted in vivo animal model of Multiple sclerosis (MS). EAE model are most suitable for analysis of immunogenetic elements (major histocompatibility complex) and for the study of histological features (inflammation, demyelination and degeneration) of the disease for screening of new treatments for MS. Some approved medications, Glatiramer acetate (GA), Natalizumab and Mitoxantron, were developed directly from studies in EAE. Several trails are ongoing in MS after success in EAE. The present review aimed to present and future treatment options for EAE model.
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